kidney injury — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T37596	Terevalefim		c-Met/HGFR
	Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.		c-Met/HGFR
T16724	Razuprotafib	AKB-9778	Phosphatase , Others
	Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor (IC50: 50 nM). Razuprotafib is effective for the activation of Tie-2 and is protective against acute kidney injury.		Phosphatase , Others
T14002	12-Ketodeoxycholic acid		Endogenous Metabolite
	12-Ketodeoxycholic acid, a bile acid and kidney metabolite, serves as a detectable marker for kidney injury [1].		Endogenous Metabolite
T10353	APX-115 free base	Ewha-18278 free base	NADPH-oxidase , NADPH
	APX-115 free base (Ewha-18278 free base) (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kid...		NADPH-oxidase , NADPH
T2870	Matrine	Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine	Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
	Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.		Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
T1615	Irbesartan	SR-47436,BMS-186295	Apoptosis , RAAS
	Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist.		Apoptosis , RAAS
T2131	Articaine hydrochloride	Ultracaine,Articaine HCl,Hoe-045	Sodium Channel
	Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.		Sodium Channel
T76251L	Ac-FEID-CMK TFA		Pyroptosis
	Ac-FEID-CMK TFA is a selective zebrafish GSDMEb-derived peptide inhibitor that reduces mortality and renal injury in infectious shock.Ac-FEID-CMK TFA inhibits pyroptosis in vivo, attenuates septic AKI (acute kidney injur...		Pyroptosis
T10354	APX-115	Ewha-18278	NADPH-oxidase
	APX-115 (Ewha-18278) (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.		NADPH-oxidase
T22311	Djenkolic Acid	jengkolic acid,Djenkolate,S,S'-Methylenebiscysteine	Others
	Djenkolic Acid (S,S'-Methylenebiscysteine) is a naturally occurring sulfur-containing amino acid extracted from djenkol beans(Archidendron pauciflorum), which is native to Southeast Asia. It is an uncommon but important ...		Others
T28222	5-Hydroxy-1-methylhydantoin	HD-003,HD003,NZ419,NZ-419,HD 003,NZ 419	Bradykinin Receptor
	5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to con...		Bradykinin Receptor
T61262	ZLD2218
	ZLD2218, a potent inhibitor of BRD4 with an IC50 value of 107 nM, has been demonstrated to mitigate kidney injury and fibrosis through extensive studies.
T36509	U-74389G	U-74389G,Methylated Tirilazad
	U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.[1],[2],[3],[4]
T38616	Teprasiran	QPI-1002
	Teprasiran (QPI-1002) is an RNA-based compound that transiently suppresses p53-dependent apoptosis, a process involved in the development of acute kidney injury (AKI).
T68328	Modimelanotide
	Modimelanotide is a melanocortinergic peptide drug derived from α-melanocyte-stimulating hormone (α-MSH) which was under development for the treatment of acute kidney injury. It acts as a non-selective melanocortin recep...
T76251	Ac-FEID-CMK
	Ac-FEID-CMK, a potent peptide inhibitor derived from zebrafish-specific GSDMEb, effectively reduces mortality and kidney injury during septic shock by inhibiting pyroptosis and mitigating acute kidney injury (AKI) in viv...
T79790	ALPK1-IN-3		NF-κB
	ALPK1-IN-3,serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhances survival in animal models of sepsis-induced acute kidney injury [1].		NF-κB
T81267	RIPK3-IN-4		RIP kinase
	RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor that mitigates necroptosis, inflammatory responses, and HK-2 cell damage. It alleviates acute kidney injury by attenuating Cisplatin- and I/R-induced kidney damage, along wit...		RIP kinase
T78802	SIRT5 inhibitor 6		Sirtuin
	SIRT5 Inhibitor 6 is a potent, selective, and substrate-competitive inhibitor of SIRT5, exhibiting an IC50 of 3.0 μM, and demonstrates therapeutic potential for treating septic acute kidney injury (AKI) in vivo [1].		Sirtuin
T73404	Dalargin
	Dalargin, a potent δ-opioid receptor agonist, demonstrates efficacy in mitigating cell death induced by Gentamicin and exhibits nephroprotective effects against Gentamicin-induced kidney injury. Additionally, Dalargin po...